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Journal of Pharmacology And Experimental Therapeutics, Vol. 146, Issue 3, 276-279, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

THE PHYSIOLOGICAL DISPOSITION OF C14-SEROTONIN IN THE RAT UTERUS

Solomon H. Snyder 1, Richard J. Wurtman 1, Julius Axelrod 1, and Elizabeth W. Chu 1

1 Laboratory of Clinical Science, National Institute of Mental Health, and Department of Pathologic Anatomy, Clinical Center, National Institutes of Health, Bethesda, Maryland

C14-serotonin is taken up and retained for long periods of time by uterus, heart, and spleen. The C14-amine is firmly bound by constituents in the cell sap of the uterus, by the blood elements in the spleen, and by a combination of these as well as by a small granule fraction in the heart.

Reserpine, but not lysergic acid diethylamide, nor compound 48-80, can release bound C14-serotonin horn uterus and spleen.

There is a greater concentration of C14-serotonin in the uterus during the diestrus phase of the estrous cycle than during estrus.

Accepted on August 21, 1964






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Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.