JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hook, J. B.
Right arrow Articles by Williamson, H. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hook, J. B.
Right arrow Articles by Williamson, H. E.
Journal of Pharmacology And Experimental Therapeutics, Vol. 146, Issue 2, 265-269, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

ADDITION OF THE NATRURETIC ACTION OF SKF 525-A TO THE ACTION OF CERTAIN OTHER NATRURETIC AGENTS

Jerry B. Hook 1 and Harold E. Williamson 1

1 Department of Pharmacology, College of Medicine, State University of Iowa, Iowa City, Iowa

The natruretic action of SKF 525-A in the dog has been studied during maximal natruresis produced by a variety of mechanisms. Infusion of SKF 525-A into the renal artery produced a significant natruretic response during the maximal natruresis produced by chlormerodrin, hydrochlorothiazide, acetazolamide, ethacrynic acid and the pteridine Wy-3654. This would suggest that SKF 525-A inhibits renal sodium transport in a different manner than do these agents.

Demonstration of a significant natruretic response to SKF 525-A in chronically adrenalectomized dogs indicates that the primary action of this compound is not inhibition of aldosterone.

Accepted on July 10, 1964






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.