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Journal of Pharmacology And Experimental Therapeutics, Vol. 146, Issue 2, 225-235, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

ENHANCED ANDROGEN HYDROXYLASE ACTIVITY IN LIVER MICROSOMES OF RATS AND DOGS TREATED WITH PHENYLBUTAZONE

A. H. Conney 1 and K. Schneidman 1

1 The Wellcome Research Laboratories, Burroughs Wellcome & Co.(U.S.A.) Inc., Tuckahoe, New York

Treatment of immature rats and dogs with phenylbutazone increased several-fold the activity of enzymes in liver microsomes that hydroxylate testosterone and Dgr4-androstene-3,17-dione. Treatment of rats with phenylbutazone or phenobarbital stimulated a minor pathway of corticosteroid metabolism to polar metabolites chromatographically similar to hydroxylated substrate. Administration of the carcinogenic hydrocarbon 3-methylcholanthrene to rats did not stimulate polar metabolite formation but markedly inhibited the microsomal metabolism of corticosteroids to metabolites chromatographically less polar than the substrate.

Accepted on July 10, 1964






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Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.