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Journal of Pharmacology And Experimental Therapeutics, Vol. 146, Issue 2, 209-214, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

THE CHRONOTROPIC ACTION OF SEROTONIN STUDIED BY DIRECT PERFUSION OF THE SINUS NODE

Thomas N. James 1

1 Section on Cardiovascular Research, Henry Ford Hospital, Detroit, Michigan

In contrast to its reported accelerating action in isolated heart preparations, serotonin has only a negative chronotropic effect on direct perfusion of the sinus node in vivo. There is no significant cholinergic component in this local slowing effect. Certain observations suggest the bradycardia may be a direct action on sinus node fibers, but an antiadrenergic mechanism has not been excluded.

Accepted on July 22, 1964






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Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.