JPET Celsis microsomes equal better data

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shore, P. A.
Right arrow Articles by Alpers, H. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shore, P. A.
Right arrow Articles by Alpers, H. S.
Journal of Pharmacology And Experimental Therapeutics, Vol. 146, Issue 2, 194-199, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

BINDING AND RELEASE OF METARAMINOL: MECHANISM OF NOREPINEPHRINE DEPLETION BY agr-METHYL-M-TYROSINE AND RELATED AGENTS

P. A. Shore 1, D. Busfield 1, and H. S. Alpers 1

1 Department of Pharmacology, University of Texas Southwestern Medical School, Dallas, Texas

l-Metaraminol, but not d-metaraminol or agr-methyl-m-tyramine, is rapidly taken up and retained by heart. After treatment with l-metaraminol or dl-agr-methyl-m-tyrosine (agr-MMT), metaraminol persists for days in heart and brain, but disappears rapidly from liver. Metaraminol is not taken up by hearts of immunosympathectomized rats. Uptake is inhibited by drugs known to inhibit norepinephrine uptake (reserpine, imipramine, guanethidine). Metaraminol in heart is released by norepinephrine or by drugs known to release norepinephrine (reserpine, guanethidine, tyramine). A stoichiometric relationship is found at most times between norepinephrine depletion and metaraminol uptake. d-Metaraminol is not retained by heart, nor does it deplete heart norepinephrine. It is concluded that l-metaraminol is the active norepinephrine-depleting agent following injection of agr-MMT and that metaraminol exchanges with norepinephrine at adrenergic nerve endings on a mole-for-mole basis.

Accepted on August 3, 1964




This article has been cited by other articles:


Home page
 ScienceHome page
W. D. Reid, F. J. E. Stefano, S. Kurzepa, and B. B. Brodie
Tricyclic Antidepressants: Evidence for an Intraneuronal Site of Action
Science, April 25, 1969; 164(3878): 437 - 439.
[Abstract] [PDF]

Home page
 Arch Gen PsychiatryHome page
W. E. BUNNEY JR. and J. M. DAVIS
Norepinephrine in Depressive Reactions: A Review
Arch Gen Psychiatry, December 1, 1965; 13(6): 483 - 494.
[Abstract] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.