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Journal of Pharmacology And Experimental Therapeutics, Vol. 146, Issue 2, 175-179, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

NEUROMUSCULAR BLOCK AS A POSSIBLE MECHANISM OF DEATH IN AMPHETAMINE POISONING

D. I. Peterson 1, M. G. Hardinge 1, and B. E. Tilton 1

1 Department of Pharmacology, School of Medicine, Loma Linda University, Loma Linda, California

Amphetamine sulfate produces neuromuscular block in the rat phrenic nerve-diaphragm preparation at concentrations below those found in the mucles of rats dying from this substance. This block is enhanced by increase in temperature and the addition of lactate. Neuromuscular block may be a cause of death from amphetamine poisoning in experimental animals.

Other sympathomimetic amines also cause neuromuscular block in vitro. The blocking concentration of different compounds varies widely within the series of drugs tested.

Accepted on July 22, 1964






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Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.