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1 Department of Pharmacology, Harvard Medical School, Boston, Massachusetts
The effects of d-amphetamine upon various types of behavior were studied in normal and in reserpine-treated pigeons. d-Amphetamine suppressed the high rates of responding generated by the fixed-ratio component and by the terminal portions of the fixed-interval component of a multiple schedule of food reinforcement. Over the same range of doses, d-amphetamine increased rates of responding during the early portions of the fixed-interval component. The rate-increasing effects of d-amphetamine were markedly enhanced in reserpine-treated pigeons. Cocaine, pipradrol and imipramine were more effective than d-amphetamine in increasing rates of responding of normal control pigeons and much less effective than d-amphetamine in increasing rates of responding of reserpine-treated pigeons. Therefore, reserpine did not cause a nonspecific enhancement of all drugs which increased rates of responding.
Accepted on August 3, 1964
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