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Journal of Pharmacology And Experimental Therapeutics, Vol. 146, Issue 2, 139-146, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

PHARMACOLOGICAL PROPERTIES OF MORPHINE-POTENTIATING SERUM OBTAINED FROM MORPHINE-TOLERANT DOGS AND MEN

Glenn F. Kiplinger 1 and Joseph W. Clift 1

1 Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, Texas

The activity of morphine-potentiating serum first reported to potentiate morphine in the rat by Kornetsky and Kiplinger has been shown to potentiate morphine in mice as measured by the hot plate analgesic test. The duration of action of the potentiation produced was at least 96 hours in the mouse. The appearance of potentiating capability in the serum of the morphinetolerant animal was related to tolerance, not to the withdrawal syndrome or to malnutrition. The potentiating capacity of the serum was not reduced by dialysis. The morphine-potentiating serum does not potentiate hexobarbital sleeping time in mice. Potentiating capacity has been demonstrated in the sera of two human morphine addicts. The role of the potentiating substance in the serum of the morphine-tolerant animal and the mechanism by which it potentiates morphine are as yet unknown.

Accepted on July 13, 1964




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G. Friedler and J. Cochin
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C. Kornetsky and G. Bain
Morphine: Single-Dose Tolerance
Science, November 29, 1968; 162(3857): 1011 - 1012.
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Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.