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Journal of Pharmacology And Experimental Therapeutics, Vol. 146, Issue 1, 92-98, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

BIPHASIC RENAL EFFECTS OF OUABAIN IN THE CHICKEN: CORRELATION WITH A MICROSOMAL Na+-K+ STIMULATED ATP-ASE

Roger F. Palmer 1 and Bohdan R. Nechay 1

1 Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida

Low doses of ouabain stimulate Na+, Cl-, water and perhaps K+ reabsorption by chicken kidney tubules. High doses have an opposite effect, that of inhibiting the reabsorption of these substances.

Low concentrations of ouabain stimulate Na+-K+ activated ATP-ase extracted from chicken kidney. High concentrations inhibit this activity.

The inhibitory effects of ouabain on Na+-K+ ATP-ase activity are antagonized by excess K+.

Because of the correlations of effects produced by ouabain on ion transport in vivo and Na+-K+ ATP-ase activity in vitro, it is proposed that the action of ouabain on electrolyte transport in the chicken kidney is mediated through Na+-K+ ATP-ase, localized in the renal tubular membrane.

A possible analogy of the effect of ouabain on renal tubular stimulation of ion transport to the inotropic action of cardiac glycosides is discussed.

Accepted on June 17, 1964






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Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.