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Journal of Pharmacology And Experimental Therapeutics, Vol. 146, Issue 1, 61-65, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

AN ADAPTIVELY STIMULATED O-DEMETHYLATING SYSTEM IN RAT LIVER MICROSOMES AND ITS KINETIC PROPERTIES

K. J. Netter 1 and G. Seidel 1

1 Department of Pharmacology, University of Hamburg, Germany

The microsomal O-demethylation of p- nitroanisole to p-nitrophenol can be stimulated by pretreatment of rats with phenobarbital and other drugs. Normal and induced microsomal O-demethylases have the same overall substrate constants. Inhibition of the stimulated enzyme by the microsome inhibitor SKF 525-A shows the same kinetic characteristics as does the control demethylase, namely noncompetitive inhibition. Available evidence may suggest the identity of original and induced O-demethylase protein.

Accepted on July 1, 1964




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