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Journal of Pharmacology And Experimental Therapeutics, Vol. 146, Issue 1, 48-53, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

PHYSIOLOGICAL DISPOSITION OF H3-NOREPINEPHRINE IN THE DEVELOPING RAT

Jacques Glowinski 1, Julius Axelrod 1, Irwin J. Kopin 1, and Richard J. Wurtman 1

1 Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland

The development of the processes for the binding, retention and metabolism of norepinephrine has been studied in the newborn rat. The uptake of norepinephrine by the heart is deficient at birth but increases rapidly after 8 days. The retention of the norepinephrine by the rat heart does not reach adult levels until 6 weeks of age.

The newborn rat is capable of metabolizing norepinephrine at birth, but cannot efficiently excrete either norepinephrine or its metabolites until the 11th day of life.

A blood-brain barrier for norepinephrine is present at birth which is almost as effective as in the adult.

Accepted on June 10, 1964




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