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*ATROPINE
*NEOSTIGMINE
*PHYSOSTIGMINE
*PILOCARPINE
*SUCCINYLCHOLINE
*TUBOCURARINE
Journal of Pharmacology And Experimental Therapeutics, Vol. 146, Issue 1, 123-128, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

THE INFLUENCE OF CHOLINERGIC AND ANTICHOLINERGIC DRUGS ON EGG DEPOSITION BY A ROTIFER

Lewis A. Lindner 1 and Harold Goldman 1

1 Research Division, Department of Psychiatry, Ohio State University, Columbus, Ohio

The response of an infra-annelid metazoan to agents which affect acetylcholine systems in more advanced organisms has been studied. Most notably, acetylcholine reversibly blocks egg deposition by the bdelloid rotifer Philodina acuticornis at an ED50 concentration of 6 x 10-5 M; no other gross functional or structural effects were noted up to lethal concentrations, 6 x 10-2 M. Physostigmine and neostigmine neither blocked egg deposition nor augmented the effect of acetylcholine; on the contrary, these two drugs, as well as atropine, tubocurarine, succinylcholine, and local anesthetics, decreased the egg retention produced by acetylcholine.

Accepted on July 24, 1964






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