JPET xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mitchell, C. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mitchell, C. L.
Journal of Pharmacology And Experimental Therapeutics, Vol. 146, Issue 1, 1-6, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

A COMPARISON OF DRUG EFFECTS UPON THE JAW JERK RESPONSE TO ELECTRICAL STIMULATION OF THE TOOTH PULP IN DOGS AND CATS

C. L. Mitchell 1

1 Department of Pharmacology, College of Medicine, State University of Iowa, Iowa City, Iowa

The effects of morphine, pentobarbital and chlorpromazine upon the threshold voltage required to elicit a response to tooth pulp stimulation in the dog and the cat were quantitatively compared. In addition, a comparison was made of the variability among the animals to both the reaction to tooth pulp stimulation and the magnitude of drug effect.

All three of the compounds produced a greater elevation in tooth pulp thresholds than did saline in the dog. However, considerable variation existed among the dogs with respect to the magnitude of drug effect. In the cat, only morphine and chlorpromazine produced an elevation in tooth pulp thresholds significantly greater than saline. Chlorpromazine was found to be approximately one-half as potent as morphine in elevating tooth pulp thresholds in the cat. In addition, the variability among the cats in response to the drugs was less than in the dog.

It was concluded that a species difference exists between the dog and the cat with regard to both the response to tooth Pulp stimulation and the effect of drugs upon the reaction to tooth pulp stimulation.

Accepted on June 9, 1964




This article has been cited by other articles:


Home page
 Pharmacol. Rev.Home page
D. Le Bars, M. Gozariu, and S. W. Cadden
Animal Models of Nociception
Pharmacol. Rev., December 1, 2001; 53(4): 597 - 652.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.