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Journal of Pharmacology And Experimental Therapeutics, Vol. 145, Issue 3, 393-398, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

EVALUATION IN MAN OF THE EFFECTS OF AN ANTICHOLINERGIC AGENT ON GASTRIC EMPTYING BY A QUANTITATIVE X-RAY METHOD

G. Sacchetti 1, F. B. Nicolis 1, and L. Roncoroni 1

1 Medical Department, Clinical Research Division, Lepetit S.p.A., Department of Medical Statistics and Biometrics and Department of Radiology of the University, Milan, Italy

A quantitative X-ray method, based on the planimetric measurement of the raliopaque gastric areas on radiographs taken at several time intervals after administration of a barium meal, was used in the evaluation of the effects on gastric emptying of the administration of levomepate [tropine (-) agr-methyltropate, TMT], in comparison with atropine and placebo. The use of this method proved to be efficient, pointed to the existence of a linear regression of the log of the radiopaque gastric area on the log of time and demonstrated that TMT is significantly more active than atropine in inhibiting gastric motility.

Accepted on May 19, 1964






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Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.