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Journal of Pharmacology And Experimental Therapeutics, Vol. 145, Issue 3, 351-356, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

DISTRIBUTION IN PLASMA, UPTAKE BY THE HEART AND EXCRETION OF OUABAIN-H3 IN HUMAN SUBJECTS

B. H. Marks 1, S. Dutta 1, J. Gauthier 1, and D. Elliott 1

1 Departments of Pharmacology and Surgery, Ohio State University College of Medicine, Columbus, Ohio

Ouabain-H3 was administered intravenously to a number of human subjects. Ouabain disappeared from plasma at a rate which suggested processes with half-lives of approximately 3 minutes and 5 hours. Ouabain-H3 was excreted primarily in urine, with biliary excretion being of much less importance. Ousbain was excreted primarily in unchanged form—evidence for the presence of ouabain metabolites was not obtained. Coronary arteriovenous difference of ouabain-H3 was present only for the first4 minutes following administration. A period of extracorporeal circulation did not regularly extract ouabain from heart tissue.

Accepted on May 22, 1964






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