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1 Departments of Psychiatry, Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida
The use of periodate oxidation under the prescribed conditions has resulted in a sensitive, specific, and rapid method for the quantitative determination of dopamine and dopa in diverse biological material. This procedure, in conjunction with one previously described, allows the differential estimation of dopamine, dopa, norepinephrine and epinephrine in the same Al2O3-purified extract. Several other methods have been critically evaluated and compared to ours.
From a study of a large number of analogs of dopamine, the specificity of the method was demonstrated.
Based on a study of the distribution of dopamine and dopa in several animals, we could not confirm the presence of dopa in the CNS (less than 0.05 µg/g), and found only about 1/50 the amount of dopamine in the spinal cord that had been reported by some investigators. A possible explanation for this discrepancy was presented.
Our results from several cases of human neural tumors were confirmed biochemically by gas chromatography and diagnostically by surgical pathology.
Accepted on May 13, 1964
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