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Journal of Pharmacology And Experimental Therapeutics, Vol. 145, Issue 2, 252-265, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

THE PENETRATION OF 2-PAM-C INTO BRAIN AND THE EFFECT OF CHOLINESTERASE INHIBITORS ON ITS TRANSPORT

H. Firemark 1, C. F. Barlow 1, and L. J. Roth 1

1 Department of Pharmacology and Department of Medicine, The University of Chicago, Chicago, Illinois

The penetration of 2-PAM-C14 into selected regions of rat brain has been measured. Treatment with toxic doses of the alkylphosphate cholinesterase inhibitor Dipterex increased the concentration of 2-PAM-C14 in four of the eight brain regions analyzed. Other cholinesterase inhibitors, hypercapnia and convulsions did not produce a similar increase in the concentration of 2-PAM-C14 in brain. The experimental data suggest that 2-PAM is actively transported by brain in vitro, and that Dipterex inhibits this transport. It has been Proposed that 2-PAM may be transported out of brain in vivo.

Accepted on April 8, 1964






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Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.