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Journal of Pharmacology And Experimental Therapeutics, Vol. 145, Issue 2, 247-251, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

A SENSITIVE FLUOROMETRIC ASSAY FOR MORPHINE IN PLASMA AND BRAIN

Harvey Kupferberg 1, Alan Burkhalter 1, and E. Leong Way 1

1 Department of Pharmacology and School of Pharmacy, University of California Medical Center, San Francisco, California

A sensitive fluornometric method for the estimation of morphine in plasma and brain has been described. The basis of this method is the conversion of morphine to pseudomorphine, a highly fluorescent compound. As little as 0.1 microgram of morphine can be measured in a tissue sample with good precision and a high degree of specificity.

The same procedure can be modified to measure normorphine, n-allyl-normorphine, dihydromorphine, and 6-monoacetyl morphine in biologic fluid. Compounds that do not interfere with this method are the morphinans, codeine and its derivatives, dihydromorphinone, diacetylmorphine, apomorphine, mepenidine, anileridine and methadone.

Accepted on April 7, 1964




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S. Spector and C. W. Parker
Morphine: Radioimmunoassay
Science, June 12, 1970; 168(3937): 1347 - 1348.
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Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.