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Journal of Pharmacology And Experimental Therapeutics, Vol. 145, Issue 1, 87-91, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECTS OF ADRENERGIC BLOCKING AGENTS AND THEOPHYLLINE ON 3', 5'-AMP-INDUCED HYPERGLYCEMIA

Gretajo Northrop 1 and R. E. Parks Jr. 1

1 Department of Pharmacology and Toxicology, The University of Wisconsin Medical School, Madison, Wisconsin

Pretreatment of intact rats with theophylline has been shown to potentiate 3', 5'-AMP-induced hyperglycemia. Administration of 1.0 mg/kg of the cyclic nucleotide, a dose insufficient to cause elevation of blood glucose, has been shown to cause significant hyperglycemia following pretreatment with theophylline (75 mg/kg).

Epinephrine and 3', 5'-AMP-induced hyperglycemia are prevented by pretreatment with the adrenergic blocking agent, dihydroergotamine (DHE) (5.6 mg/kg). Hyperglycemia in response to 3', 5'-AMP treatment occurred in adrenalectomized rats and this response could also be blocked by pretreatment with DHE.

Dichloroisoproterenol (DCI), a beta adrenergic blocking agent, in a dose of 100 mg/kg, decreased epinephrine-induced hyperglycemia by about 90% but had no effect on 3', 5'-AMP-induced hyperglycemia.

Accepted on February 19, 1964




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Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.