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Journal of Pharmacology And Experimental Therapeutics, Vol. 145, Issue 1, 71-77, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON THE CARDIOVASCULAR EFFECTS OF SYNTHETIC ELEDOISIN

Jiro Nakano 1

1 Department of Pharmacology, University of Oklahoma School of Medicine, Oklahoma City, Oklahoma

The effects of intravenous administration of synthetic eledoisin on the cardiovascular system were studied in anesthetized dogs. It was found that eledoisin decreases mean systemic arterial pressure and total peripheral resistance. On the other hand, eledoisin increases heart rate, pulmonary arterial pressure, left atrial pressure, myocardial contractile force and cardiac output initially, and then decreases the parameters except heart rate. The magnitude of the hemodynamic changes observed was essentially in proportion to the doses given. No apparent tachyphylaxis was observed. The intraarterial administration of eledoisin resulted in increases in the blood flows of the coronary, brachial and femoral arteries without any significant changes in heart rate, mean systemic arterial pressure and myocardial contractile force. In contrast, in the isolated guinea-pig atria and dog ventricular muscle strip preparations, lower concentrations of eledoisin produced no changes in the force and frequency of myocardial contraction. However, the higher concentrations of eledoisin decreased both force and frequency of contraction.

It is indicated that the cardiovascular changes following the intravenous administration of eledoisin are most likely clue to its direct vasodilator attion on the peripheral vasculatures.

Accepted on March 20, 1964




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Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.