JPET xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Eble, J. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Eble, J. N.
Journal of Pharmacology And Experimental Therapeutics, Vol. 145, Issue 1, 64-70, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

A PROPOSED MECHANISM FOR THE DEPRESSOR EFFECT OF DOPAMINE IN THE ANESTHETIZED DOG

John Nelson Eble 1

1 Biomedical Research Department, Pitman-Moore Division of The Dow Chemical Company, Indianapolis, Indiana

The effect of intravenous dopamine on systemic blood pressure in the anesthetized dog was shown to be the result of a balance between vasoconstriction in some beds (carotid and femoral) and vasodilation in others (superior mesenteric, renal, and celiac). Cardiac output was not muchaffected, but tended to be increased. The systemic depressor effect was usually unaffected or reduced, rarely blocked, by nethalide and the same was found for the dilator effect in the mesentery. The systemic pressor effect of dopamine was reversed by tolazoline, as was the constrictor effect in the separate beds.

Accepted on March 25, 1964




This article has been cited by other articles:


Home page
 Postgrad. Med. J.Home page
C. J Burton and C. R V Tomson
Management options: Can the use of low-dose dopamine for treatment of acute renal failure be justified?
Postgrad. Med. J., May 1, 1999; 75(883): 269 - 274.
[Abstract] [Full Text]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.