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Journal of Pharmacology And Experimental Therapeutics, Vol. 144, Issue 3, 393-398, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

THE HYDROXYLATION OF TYRAMINE IN THE ISOLATED CANINE HEART

C. A. Chidsey 1, G. A. Kaiser 1, and B. Lehr 1

1 Cardiology Branch, National Heart Institute, Bethesda, Maryland

Isolated canine hearts were perfused with radioactive tyramine to determine the metabolic fate of this sympathomimetic amine in the heart. Hydroxylation of tyramine to form norsynephrine was found to occur. The rate of this hydroxylation was observed to be comparable to that of the formation of norepinephrine from dopamine. Incorporation of radioactivity from tyramine into norepinephrine, however, was found to occur at a much slower rate. The ability of norsynephrine both to release and to deplete myocardial norepinephrine was found to be less than that of tyramine. It is concluded that the pharmacologic actions of tyramine result principally from the direct action of this monoamine and not from that of its hydroxylated products.

Submitted on October 28, 1963
Accepted on January 3, 1964






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Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.