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Journal of Pharmacology And Experimental Therapeutics, Vol. 144, Issue 3, 380-384, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

IN VITRO HISTAMINE RELEASE FROM RAT PERITONEAL CELLS BY BETA-MERCAPTOETHYLAMINE AND CYSTAMINE

Gale E. Demaree 1, Roy L. Mundy 1, Melvin H. Heiffer 1, and David P. Jacobus 1

1 Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D. C.

Cystamine and beta - mercaptoethylamine (MEA) induced a release of histamine from suspensions of peritoneal cells of the rat. The response to cystamine was proportional to the logarithm of the concentration over a range of 10-4 M to 10-2 M but the response to MEA increased and then decreased with increasing concentrations. The percentage of histamine released from peritoneal cells in response to both cystamine and MEA was proportional to the time of incubation from 20 to 90 minutes. Aminoethanethiosulfuric acid at comparable concentrations did not induce release of histamine from peritoneal cells.

MEA was rapidly converted to cystamine in peritoneal cell suspensions. The evidence supports the hypothesis that histamine release in response to MEA, both in vitro and in vivo, is due to the cystamine formed from MEA.

Submitted on August 28, 1963
Accepted on January 6, 1964






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Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.