![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
1 Laboratory of Clinical Science, National Institute of Mental Health, and Laboratory of Biochemical Pharmacology, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland
Specific methods for the estimation of C14-histamine and its metabolites, methylhistamine, imidazoleacetic acid, and imidazoleacetic acid riboside are described. Circulating histamine is rapidly metabolized in the intact mouse, but small amounts of histamine persist after 48 hours. Methylhistamine is quickly formed and after 30 minutes is present in higher concentrations than histamine. The major metabolic products which are formed and retained in both rat and mouse tissues are imidazoleacetic acid and its riboside. Histamine is unequally distributed among tissues of the mouse and rat. After 24 hours, the rat spleen contains more histamine than any other tissue.
Submitted on November 15, 1963
This article has been cited by other articles:
|
|
 |
|
  G. D. Prell, G. P. Martinelli, G. R. Holstein, J. Matulic-Adamic, K. A. Watanabe, S. L. F. Chan, N. G. Morgan, M. A. Haxhiu, and P. Ernsberger Imidazoleacetic acid-ribotide: An endogenous ligand that stimulates imidazol(in)e receptors PNAS, September 14, 2004; 101(37): 13677 - 13682. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Vaziri, K. Dang, and G. H. Anderson Evidence for Histamine Involvement in the Effect of Histidine Loads on Food and Water Intake in Rats J. Nutr., August 1, 1997; 127(8): 1519 - 1526. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. E. Fischer and S. H. Snyder Histamine Synthesis and Gastric Secretion after Portacaval Shunt Science, November 19, 1965; 150(3699): 1034 - 1035. [Abstract] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
