JPET xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kato, H.
Right arrow Articles by Buckley, J. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kato, H.
Right arrow Articles by Buckley, J. P.
Journal of Pharmacology And Experimental Therapeutics, Vol. 144, Issue 2, 260-264, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

POSSIBLE SITES OF ACTION OF THE RESPIRATORY STIMULANT EFFECT OF DOXAPRAM HYDROCHLORIDE

Hitoshi Kato 1 and Joseph P. Buckley 1

1 Department of Pharmacology, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania

Doxapram hydrochloride, 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone hydrochloride hydrate, has been shown to be a potent respiratory stimulant acting mainly through direct stimulation of central respiratory centers. Data have been presented which indicate that the compound produces a mild stimulation of carotid chemoreceptors. The compound also produces a peripheral stimulating effect due to stimulation of the aortic chemoreceptors and possibly other peripheral chemoreceptors. Doxapram also produced pressor responses through both central and peripheral mechanisms.

Submitted on July 17, 1963
Accepted on January 3, 1964




This article has been cited by other articles:


Home page
 Canadian J. AnesthesiaHome page
C.-C. Wu, M. S. Mok, J.-Y. Chen, G.-J. Wu, Y.-R. Wen, and C.-S. Lin
Doxapram shortens recovery following sevoflurane anesthesia: [Le doxapram hate la recuperation apres une anesthesie au sevoflurane].
Can J Anesth, May 1, 2006; 53(5): 456 - 460.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.