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Journal of Pharmacology And Experimental Therapeutics, Vol. 144, Issue 2, 156-162, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

ALPHA AND BETA ADRENERGIC RECEPTOR MECHANISMS IN THE SYSTEMIC VENOUS BED

Gerard A. Kaiser 1, John Ross Jn. 1, and Eugene Braunwald 1

1 The Cardiology Branch, National Heart Institute, Bethesda, Maryland

The effects of isoproterenol, phenylephrine, and norepinephrine were studied in an experimental canine preparation in which cardio-pulmonary bypass permitted exclusion of the heart and lungs, and allowed continuous measurement of alterations of intravascular blood volume. In all experiments the beta adrenergic receptor stimulator, isoproterenol, resulted in a decrease in systemic vascular blood volume, similar to that observed with the alpha receptor stimulating agents, phenylephrine and norepinephrine. By the use of appropriate adrenergic blocking agents, it was demonstrated that the systemic venous bed contains both beta and alpha adrenergic receptors. Thus, in contrast to the opposing actions of these receptors in the arterial bed, stimulation of either alpha or beta receptors produces venoconstriction.

Submitted on November 15, 1963
Accepted on December 23, 1963




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Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.