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Journal of Pharmacology And Experimental Therapeutics, Vol. 144, Issue 1, 83-88, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

THE CHRONOTROPIC ACTION OF TYRAMINE STUDIED BY DIRECT PERFUSION OF THE SINUS NODE THROUGH ITS ARTERY

Thomas N. James 1 and Reginald A. Nadeau 1

1 Section on Cardiovascular Research, Henry Ford Hospital, Detroit, Michigan

Tyramine injected into the sinus node artery produces more tachycardia (both in peak level and duration) in normal than in reserpinized dogs. The duration of sinus tachycardia from tyramine is much longer than that from norepinephnine administered in the same manner. The responsiveness to tyramine by the sinus node of reserpinized dogs can be transiently restored to normal with norepinephrine, hut not by isoproterenol. Norepinephrine injected into the sinus node artery of reserpinized dogs does not restore the accelerative response to stimulation of the stellate ganglion.

Submitted on September 23, 1963
Accepted on December 2, 1963






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Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.