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Journal of Pharmacology And Experimental Therapeutics, Vol. 144, Issue 1, 8-11, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

USE OF HINDLIMB REFLEXES OF THE CHRONIC SPINAL DOG FOR COMPARING ANALGESICS

W. H. Martin 1, C. C. Eades 1, H. F. Fraser 1, and A. Wikler 1

1 National Institute of Mental Health, Addiction Research Center, PHS Hospital, Lexington, Kentucky

A method, using the hindlimb reflexes of chronic spinal dogs for determining the relative potency of morphine, codeine and I-K-1, which is reproducible and sensitive has been described. Since the actions of the drugs upon effector systems innervated by portions of the nervous system above and below the level of transection can be easily studied together, a qualitative and quantitative assessment of the drugs' actions can be made.

Submitted on August 7, 1963
Accepted on November 27, 1963




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Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.