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Journal of Pharmacology And Experimental Therapeutics, Vol. 144, Issue 1, 138-141, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

A COMPARISON OF THE RESPONSES TO l-SPARTEINE AND OXYTOCIN IN ISOLATED HUMAN UTERINE MUSCLES

Ira Rosenblum 1 and Arthur A. Stein 1

1 Departments of Pharmacology and Pathology, Albany Medical College, Albany, New York

Comparisons have been made between the effects of l-sparteine and oxytocin on isolated human uterine muscles. Both drugs can initiate spontaneous contractions and this effect is antagonized by addition of medroxyprogesterone to the fluid bath.

Neither l-sparteine nor oxytocin could initiate spontaneous contractions in muscles "polaized" in K2SO4-Ringer solution. These findings suggest that l-sparteine has its main action on membrane function rather than directly on the contractile elements of uterine muscle.

Submitted on October 14, 1963
Accepted on December 9, 1963






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