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Journal of Pharmacology And Experimental Therapeutics, Vol. 144, Issue 1, 12-16, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

THE ANALGESIC EFFICACY AND RESPIRATORY EFFECTS IN MAN OF A BENZOMORPHAN "NARCOTIC ANTAGONIST"

Louis Lasagna 1, Thomas J. De Kornfeld 1, and John W. Pearson 1

1 Departments of Medicine (Division of Clinical Pharmacology) and of Pharmacology and Experimental Therapeutics, Johns Hopkins University School of Medicine, and Department of Anesthesiology, Baltimore City Hospitals, Baltimore, Maryland

Win 20,740, 2-cyclopropylmethyl-2'-hydroxy-5,9-dimethyl-6,7-benzomorphan, a compound which is a narcotic antagonist in experimental animals, has been shown to be a potent analgesic agent in man. Doses as low as 0.25 mg, given by mouth or injection, provide effective pain relief. The failure to observe serious obtundation or respiratory depression with doses four to eight times this amount suggests that Win 20,740 has a lower "ceiling" for certain untoward effects than does morphine.

Submitted on July 18, 1963
Accepted on October 14, 1963




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Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.