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Journal of Pharmacology And Experimental Therapeutics, Vol. 144, Issue 1, 110-115, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON SOME CARDIAC EFFECTS OF TAURINE

J. D. Welty 1 and W. O. Read 1

1 Department of Physiology and Pharmacology, School of Medicine, University of South Dakota, Vermillion, South Dakota

Experiments were performed to determine the effect of taurine on the intracellular potassium of heart tissue. The data show that: (1) taurine, in the presence of 10-6 M epinephrine or 1.25 x 10-6 M digoxin, promotes cellular accumulation of potassium in heart slices and abolishes or reverses the loss of cell potassium when heart slices are incubated in the presence of 10-4 M epinephrine or 1.25 x 10-4 M digoxin; (2) epinephnine, digoxin and procaine amide increase the conversion of taunine to isethionic acid by heart slices, quinidine has no effect, while acetylcholine depresses the conversion; (3) taurine, in the intact dog heart, prevents the efflux of potassium which accompanies lange doses of epinephrine.

Submitted on July 1, 1963
Accepted on November 27, 1963




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Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.