JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Graham, M. H.
Right arrow Articles by Eckstein, J. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Graham, M. H.
Right arrow Articles by Eckstein, J. W.
Journal of Pharmacology And Experimental Therapeutics, Vol. 143, Issue 3, 340-343, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF NOREPINEPHRINE ON PLASMA NONESTERIFIED FATTY ACID CONCENTRATIONS AFTER ADMINISTRATION OF COCAINE

Michael H. Graham 1, Francois M. Abboud 1, and John W. Eckstein 1

1 Cardiovascular Research Laboratories, Department of Internal Medicine, State University of Iowa, College of Medicine, Iowa City, Iowa

The effects of norepinephrine on arterial pressure and plasma concentration of NEFA (nonesterified fatty acids) were compared in dogs before and after administration of cocaine. Increments in plasma NEFA concentration as well as in arterial pressure in response to norepinephrine were found to be increased significantly. Eliminating hepatic circulation did not block the potentiation indicating that reduced hepatic uptake of NEFA cannot entirely explain the augmenting effects. The augmentation was not due to a cumulative effect of norepinephrine since 2 consecutive infusions of the catecholamine without cocaine did not produce potentiation.

Submitted on August 26, 1963
Accepted on October 23, 1963






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.