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Journal of Pharmacology And Experimental Therapeutics, Vol. 143, Issue 3, 319-325, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics


FORMATION OF beta-PHENYLETHYLAMINE IN MAMMALIAN TISSUE AND ITS EFFECT ON MOTOR ACTIVITY IN THE MOUSE

Teruo Nakajima 1, Yasuo Kakimoto 1, and Isamu Sano 1

1 The Department of Neuropsychiatry, Osaka University Medical School, Osaka, Japan

The occurrence of beta-phenylethylamine in the tissues of rabbits treated with a monoamine oxidase inhibitor has been demonstrated. The tentative identification of the amine was confirmed with material purified from organs of rabbits which had been treated with the injection of both a monoamine oxidase inhibitor and L-phenylalanine.

The concentrations of beta-phenylethylamine in various tissues and different regions of the brain of rabbits which had been given monoamine oxidase inhibitors are reported.

The administration of beta-phenylethylamine to the mouse resulted in an increased motor activity along with an increased amount of the amine in the brain.

Submitted on July 5, 1963
Accepted on November 20, 1963







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Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.