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Journal of Pharmacology And Experimental Therapeutics, Vol. 143, Issue 3, 314-318, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

THE UPTAKE OF H3-MELATONIN IN ENDOCRINE AND NERVOUS TISSUES AND THE EFFECTS OF CONSTANT LIGHT EXPOSURE

Richard J. Wurtman 1, Julius Axelrod 1, and Lincoln T. Potter 1

1 Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland

The uptake of circulating H3-melatonin was examined in endocrine and other tissues, in cats and rats. It was found that the pineal gland, iris-choroid, ovary, and other endocrine and peripheral nervous structures took up and retained this compound. The high uptake by ovary was unrelated to hemodynamic factors. Exposure of rats to constant light markedly inhibited the

concentration of melatonin by ovary, but not by heart. Bovine pineal slices were found to concentrate H3-melatonin. Subcellular distribution studies in pineal, ovary, and adrenal showed that most of the retained H3-melatonin was confined to the soluble supernatant fraction.

Submitted on September 30, 1963
Accepted on October 28, 1963




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