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Journal of Pharmacology And Experimental Therapeutics, Vol. 143, Issue 3, 301-308, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

DISPOSITION AND FATE OF (-)-COTININE-H3 IN THE MOUSE

Edward R. Bowman 1, Eskil Hansson 1, Lennox B. Turnbull 1, Herbert McKennis Jr. 1, and CARL G. SCHMITERLöW 2

1 Department of Pharmacology, Medical College of Virginia, Richmond, Virginia
2 Department of Pharmacology, Royal Veterinary College, Stockholm, Sweden

The distribution and fate of tritium-labeled cotinine have been studied in the mouse after intravenous injection. The studies indicate a rather even distribution among various tissues, with the exception of high concentration in excretory organs, such as the kidneys and urinary bladder, and a concentration to some extent in the cerebellum. An examination of the urine revealed the presence of the metabolites demethylcotinine, hydroxycotinine and 3-pyridylacetic acid. The metabolism of cotinine thus follows in the mouse a pattern previously established in other species. The differences in distribution between nicotine and cotinine, after intravenous administration, is discussed in terms of a possible relationship to the marked pharmacological activity of nicotine and contrasting lesser activity of its metabolite, cotinine.

Submitted on August 20, 1963
Accepted on October 26, 1963






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Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.