JPET Celsis microsomes equal better data

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Journal of Pharmacology And Experimental Therapeutics, Vol. 143, Issue 3, 282-284, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

STEPWISE DEVELOPMENT OF RESISTANCE TO D-CYCLOSERINE IN STAPHYLOCOCCUS AUREUS

Warren B. Howe 1, G. Leland Melson 1, Charles H. Meridith 1, James R. Morrison 1, Martin H. Platt 1, and Jack L. Strominger 1

1 Departments of Pharmacology and Microbiology, Washington University School of Medicine, St. Louis, Missouri

The stepwise development of resistance to D-cycloserine has been observed. The most resistant organisms were more than 50 times as resistant to the antibiotic as the parent strain. No cross-resistance to 9 other antibiotics examined occurred. The mutants were identical to the parent strain by staphylococcal phage typing and by agglutinations in staphylococcal specific factor sera.

Submitted on July 17, 1963
Accepted on October 23, 1963






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Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.