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Journal of Pharmacology And Experimental Therapeutics, Vol. 143, Issue 3, 278-281, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

ANTAGONISM OF THE ANTIMALARIAL ACTION OF CHLOROQUINE BY FERRIHEMATE AND AN HYPOTHESIS FOR THE MECHANISM OF CHLOROQUINE RESISTANCE

Fred W. Schueler 1 and W. F. Cantrell 1

1 Laboratory of Parasite Chemotherapy, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland

Ferrihemic acid, a metabolite of hemin in its conversion to hematin (malarial pigment), has been found to antagonize the antimalarial action of chloroquine in mice infected with P. berghei. This antagonism has been demonstrated both by the administration of ferrihemate-chloroquine complex and by administration of ferrihemate and chloroquine separately by different routes to infected mice. The fact that ferrihemate, a material specifically elaborated by the plasmodium during its erythrocytic stages, antagonizes the action of chloroquine, a drug which acts during the erythrocytic stages, forms the basis of an hypothesis for the mechanism of chloroquine resistance of malaria.

Submitted on June 25, 1963
Accepted on November 8, 1963




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Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.