JPET xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Harman, R. E.
Right arrow Articles by Kuehl, F. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Harman, R. E.
Right arrow Articles by Kuehl, F. A., JR.
Journal of Pharmacology And Experimental Therapeutics, Vol. 143, Issue 2, 215-220, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

THE METABOLITES OF INDOMETHACIN, A NEW ANTI-INFLAMMATORY DRUG

Robert E. Harman 1, M. A. P. Meisinger 1, George E. Davis 1, and Frederick A. Kuehl JR. 1

1 Merck Sharp & Dohme Research Laboratories, Merck & Company, Inc., Rahway, New Jersey

The urinary metabolites of indomethacin in several animal species and in man have been investigated with the use of C14-labeled drug. Most of the drug is accounted for as unchanged indomethacin and its O-desmethyl and N-deschlorobenzoyl derivatives and the corresponding acyl glucuronides. Conjugation and renal excretion of indomethacin occur with lowest efficiency in the dog and the rat. The rabbit, guinea pig and monkey show an increasing degree of glucuronide conjugation and a more rapid and complete renal excretion pattern. Man rapidly excretes indomethacin in the urine entirely as the glucuronide.

Submitted on July 26, 1963
Accepted on October 2, 1963




This article has been cited by other articles:


Home page
 Drug Metab. Dispos.Home page
M. Nakajima, T. Inoue, N. Shimada, S. Tokudome, T. Yamamoto, and Y. Kuroiwa
Cytochrome P450 2C9 Catalyzes Indomethacin O-Demethylation in Human Liver Microsomes
Drug Metab. Dispos., March 1, 1998; 26(3): 261 - 266.
[Abstract] [Full Text]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.