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Journal of Pharmacology And Experimental Therapeutics, Vol. 143, Issue 2, 187-191, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

THE RELATIVE SENSITIVITIES OF DIAPHRAGM AND OTHER MUSCLES OF THE GUINEA PIG TO NEUROMUSCULAR BLOCKING AGENTS

Dermot B. Taylor 1, Rosemary D. Prior 1, and John A. Bevan 1

1 Department of Pharmacology and Brain Research Institute, UCLA Center for Health Sciences, Los Angeles, California

The sensitivity of three guinea-pig muscles, the diaphragm, latissimus dorsi and serratus anterior to neuromuscular blocking agents has been determined under in vitro conditions. With the possible exception of gallamine, the order of decreasing sensitivity was always the same—latissimus dorsi, serratus anterior and diaphragm.

The relative sensitivity of the three muscles depends not only on the structure of the neuromuscular blocking agent but on the dose employed.

The N,N'-diallyl derivative of l-curine spares isolated respiratory muscle in the guinea pig more than its corresponding dimethyl derivative and more than d-tubocurarine.

Submitted on June 24, 1963
Accepted on October 2, 1963






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