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Journal of Pharmacology And Experimental Therapeutics, Vol. 143, Issue 2, 165-168, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

INTERACTION OF CAFFEINE AND MORPHINE ON RESPIRATION

J. Weldon Bellville 1

1 Stanford University, School of Medicine, Department of Anesthesia, Stanford, California

A double-blind factorial study has been carried out to determine the respiratory effects of morphine and caffeine in terms of the alveolar ventilation-end expiratory PCO2 response curve. Caffeine at the 500-mg dose level produced significant respiratory stimulation. When given in combination with 5 or 10 mg of morphine it produced significant reduction in the respiratory depression due to the narcotic. It appears that this is a surmountable, possibly a competitive, type antagonism and there is nothing to suggest that it is more than an additive effect between these two drugs.

Submitted on December 26, 1962
Accepted on October 9, 1963






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