JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McIsaac, W. M.
Right arrow Articles by Kanda, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McIsaac, W. M.
Right arrow Articles by Kanda, M.
Journal of Pharmacology And Experimental Therapeutics, Vol. 143, Issue 1, 7-13, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

THE METABOLISM OF 1-HYDRAZINOPHTHALAZINE

William M. McIsaac 1 and Masayuki Kanda 1

1 Research Division, Cleveland Clinic Foundation, Cleveland, Ohio

A study has been made of the metabolism of C14-1-hydrazinophthalazine in rats and rabbits.

The activity of various tissues following administration of C14-1-hydrazinophthalazine has been estimated. Eighteen per cent of the dose was circulating in the blood 8 hours after intraperitoneal administration.

Excretion of metabolites of 1-hydrazinophthalazine was rapid, 75% of the radioactivity appearing in the urine in 24 hours.

The following metabolites were identified: 1-hydrazinophthalazine-O-glucuronide, N-acetyl-1-hydrazinophthalazine, unchanged 1-hydrazinophthalazine and its pyruvic hydrazone.

Quantitative estimation of these metabolites by scanning radioactive chromatograms and by isotope dilution showed that 1-hydrazinophthalazine-O-glucuronide (40-50%), 1-hydrazinophthalazine (15%), N-acetyl-1-hydrazinophthalazine (25-30%), hydroxy - 1 - hydrazinophthalazine (<5%), and hydrazinophthalazine pyruvic acid hydrazone (<5%) accounted for all the activity in urine.

1-Hydrazinophthalazine pyruvic hydrazone and N-acetyl-1-hydrazinophthalazine were less toxic than 1-hydrazinophthalazine.

1-Hydrazinophthalazine was found to be unstable at alkaline pH.

Submitted on July 23, 1963
Accepted on September 18, 1963






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.