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Journal of Pharmacology And Experimental Therapeutics, Vol. 143, Issue 1, 137-140, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF GOLD THIOMALATE ON PROTEIN DENATURATION

Donald A. Gerber 1

1 Department of Medicine of the Columbia University College of Physicians and Surgeons, the First Medical Division of Bellevue Hospital and the Edward Daniels Faulkner Arthritis Clinic, New York, N. Y.

Heat and urea denaturation of bovine serum albumin is altered in the presence of gold thiomalate. The denatured albumin formed in the presence of gold thiomalate resembles that formed in the presence of reagents which prevent the sulfhydryl disulfide interchange reaction. Gold thiomalate inhibits the reaction between ferricyanide and thiomalate. The addition of gold thiomalate to protein containing free sulfhydryl groups at room temperature does not result in the release of measurable amounts of free thiomalate.

Submitted on March 27, 1963
Accepted on September 16, 1963






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Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.