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Journal of Pharmacology And Experimental Therapeutics, Vol. 143, Issue 1, 131-136, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

ELEVATION OF PLASMA HISTAMINE LEVELS IN THE DOG FOLLOWING ADMINISTRATION OF MUSCLE RELAXANTS, OPIATES AND MACROMOLECULAR POLYMERS

W. L. Thompson 1 and R. P. Walton 1

1 Department of Pharmacology, Medical College of South Carolina, Charleston, South Carolina

The fluorimetric method of histamine assay (Shore et al., 1959) has been modified to increase sensitivity for measurement of plasma concentrations. Initial injections of d-tubocurarine, dimethyltubocurarine, and succinylcholine in dogs produced dose-related increments in plasma histamine levels and moderate hypotensive reactions. Injections of morphine, codeine and meperidine produced elevations of plasma histamine levels and hypotensive reactions, but methadone produced hypotension without elevation of plasma histamine concentrations. Acacia and PVP increased plasma histamine levels and decreased mean arterial pressures, but starch and dextran failed to evoke measurable increments of plasma histamine or hypotensive reactions. Diatrizoate, methiodal, and nicotinic acid provoked no detectable increments in arterial plasma histamine concentrations, but did cause frequent mild to moderate hypotensive reactions.

Submitted on July 19, 1963
Accepted on September 23, 1963




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Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.