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Journal of Pharmacology And Experimental Therapeutics, Vol. 142, Issue 3, 343-350, 1963
Copyright © 1963 by American Society for Pharmacology and Experimental Therapeutics

ENHANCEMENT BY RESERPINE AND agr-METHYL DOPA OF THE EFFECTS OF d-AMPHETAMINE UPON THE LOCOMOTOR ACTIVITY OF MICE

Charles B. Smith 1

1 Department of Pharmacology, Harvard Medical School, Boston, Massachusetts

Changes in the effect of d-amphetamine upon locomotor activity of grouped mice caused by reserpine or by agr-methyl dopa depended upon the time which elapsed between the injection of reserpine or agr-methyl dopa and the injection of d-amphetamine. Following treatment of mice with reserpine or agr-methyl dopa a marked enhancement of the activity-increasing effect of d-amphetamine occurred. The activity-increasing effect of cocaine and of pipradrol was not enhanced after reserpine, indicating a specific action of reserpine upon the effect of d-amphetamine. The enhancement of the activity-increasing effect of d-amphetamine after agr-methyl dopa followed changes in brain norepinephrine more closely than changes in either brain 5-HT or dopamine. The activity-increasing effect of l-dopa was also enhanced after agr-methyl dopa. These experiments suggest that in the central nervous system d-amphetamine acts primarily as a direct-acting sympathomimetic amine although some indirect action cannot be excluded.

Submitted on June 6, 1963
Accepted on September 6, 1963




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Copyright © 1963 by the American Society for Pharmacology and Experimental Therapeutics.