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*EPINEPHRINE
*GUANETHIDINE
*RESERPINE
Journal of Pharmacology And Experimental Therapeutics, Vol. 142, Issue 1, 76-82, 1963
Copyright © 1963 by American Society for Pharmacology and Experimental Therapeutics

MICROCIRCULATION: EFFECTS OF GUANETHIDINE AND RESERPINE

Arthur M. Zimmerman 1 and Laurence S. Harris 1

1 Department of Pharmacology, State University of New York Downstate Medical Center, Brooklyn, New York

The effects of two antihypertensive agents, guanethidine and reserpine, were evaluated on the microcirculation by direct microscopic studies of rat mesoappendix vasculature. The administration of guanethidine (7.5 mg/kg) was found to produce a 3-fold sensitization to topically applied epinephrine within 10 minutes. Sensitization to topical epinephrine was recorded 30 minutes after the administration of reserpine (1.0 mg/kg). The chronic administration of both drugs produced a pattern of sensitization very similar to that of topically applied epinephrine.

The increased reactivity of the peripheral vascular bed (rat mesocecum), following treatment with reserpine and guanethidine, is discussed in relation to the effects of reserpine and guanethidine on the heart and other tissues.

Submitted on December 31, 1962
Accepted on July 11, 1963




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 ANGIOLOGYHome page
B. M. Altura and B. W. Zweifach
Influence of Reserpine and Guanethidine On Vascular Reactivity and Antihistamine Constrictor Action in the Microcirculation
Angiology, July 1, 1966; 17(7): 493 - 502.
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Copyright © 1963 by the American Society for Pharmacology and Experimental Therapeutics.