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Journal of Pharmacology And Experimental Therapeutics, Vol. 142, Issue 1, 132-136, 1963
Copyright © 1963 by American Society for Pharmacology and Experimental Therapeutics

AN AZASTEROL THAT INDUCES HYPOCHOLESTEROLEMIA IN RATS

R. E. Ranney 1, D. L. Cook 1, W. E. Hambourger 1, and R. E. Counsell 1

1 Divisions of Biological and Chemical Research, G. D. Searle & Co., Chicago, Illinois

22, 25-Diazacholestanol dihydrochloride, SC-11952, has been shown to be a potent hypocholesterolemic agent in the normal rat and in the rat made hypercholesterolemic with propylthiouracil. No obvious, acute, cardiovascular or central nervous side effects have been observed at doses as great as 10 times the minimal effective hypocholesterolemic dose. The compound does induce an accumulation in liver and plasma of desmosterol.

Submitted on March 8, 1963
Accepted on July 8, 1963






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