JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zak, S. B.
Right arrow Articles by Greengard, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zak, S. B.
Right arrow Articles by Greengard, P.
Journal of Pharmacology And Experimental Therapeutics, Vol. 141, Issue 3, 392-398, 1963
Copyright © 1963 by American Society for Pharmacology and Experimental Therapeutics

THE DETERMINATION AND PHYSIOLOGICAL DISTRIBUTION OF DIPYRIDAMOLE AND ITS GLUCURONIDES IN BIOLOGICAL MATERIAL

Sylvia B. Zak 1, H. H. Tallan 1, Gertrude P. Quinn 1, I. Fratta 1, and P. Greengard 1

1 Department of Biochemistry, Geigy Research Laboratories, Ardsley, New York

An extremely sensitive spectrofluorimetric method has been developed for the separate estimation of dipyridamole and of its metabolites in biological fluids and tissues.

See table in the PDF file

The half-life of dipyridamole in rabbit plasma is 75 minutes and the drug disappears rapidly from the tissues as well. Dipyridamole glucuronides were found in plasma and, unexpectedly, in tissues.

A second metabolite of dipyridamole has been found in the bile and identified as dipyridamole diglucuronide.

Submitted on March 29, 1963
Accepted on June 12, 1963






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1963 by the American Society for Pharmacology and Experimental Therapeutics.