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*TUBOCURARINE
Journal of Pharmacology And Experimental Therapeutics, Vol. 141, Issue 3, 356-362, 1963
Copyright © 1963 by American Society for Pharmacology and Experimental Therapeutics

BLOOD-BRAIN BARRIER TO d-TUBOCURARINE

Ellis N. Cohen 1

1 Department of Anesthesia, Stanford University School of Medicine, Palo Alto, California

A study of blood-brain barrier in sixteen animals subjected to a variety of experimental conditions, plus clinical studies in three patients, failed to demonstrate the passage of d-tubocurarine from plasma into the cerebrospinal fluid following intravenous or intraarterial injection. A theoretical explanation of this barrier is readily provided in terms of lipid solubility and dissociation constant for d-tubocurarine.

Submitted on April 30, 1963
Accepted on June 3, 1963






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