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Journal of Pharmacology And Experimental Therapeutics, Vol. 141, Issue 3, 343-348, 1963
Copyright © 1963 by American Society for Pharmacology and Experimental Therapeutics

THE PHARMACOLOGY OF METHANE SULFONYL CHOLINE

Eileen T. Eckhardt 1 and F. W. Schueler 1

1 Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana

The pharmacology of methane sulfonyl choline (MSC) can be summarized as follows: (1) It appears to have its major pharmacological action as a ganglionic stimulating agent, presumably acting by depolarizing ganglion cells, in a manner analogous to high doses of ACh. (2) The compound possesses neuromuscular blocking activity believed due to a persistent depolarization of the endplate. This also appears analogous to ACh. (3) MSC causes death by respiratory paralysis probably due to neuromuscular blockade. (4) The compound can inhibit cholinesterase only in high doses; therefore, this is not believed to be its primary mechanism of action in producing neuromuscular blockade.

Submitted on April 8, 1963
Accepted on June 13, 1963






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