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Journal of Pharmacology And Experimental Therapeutics, Vol. 141, Issue 3, 326-332, 1963
Copyright © 1963 by American Society for Pharmacology and Experimental Therapeutics

AN ANALYSIS OF THE EFFECTS OF MERALLURIDE AND OUABAIN ON SODIUM EXCRETION BY STOP-FLOW AND SLOW-FLOW TECHNIQUES

H. L. White 1 and Doris Rolf 1

1 Department of Physiology, Washington University School of Medicine, St. Louis, Missouri

With dogs in mannitol-induced diuresis the [Na]u of slow urine flow is lower than that of the stop-flow distal sodium minimum, with or without meralluride. Free flow [Na]u and distal minimum [Na]u are significantly raised after meralluride. Slow flow [Na]u is usually not raised after meralluride, but is always raised after ouabain. When a dog is in slow flow with low [Na]u, there may be no increase in [Na]u with a 2- or 3-fold increase in glomerular filtration rate. The evidence for a distal as well as a proximal action is stronger for ouabain than for meralluride, but this possibility cannot be excluded for the latter.

Submitted on January 31, 1963
Accepted on June 17, 1963






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Copyright © 1963 by the American Society for Pharmacology and Experimental Therapeutics.